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The main reasons for this are twofold: First, although the rectum and parts of the distal colon in humans have no direct vagus nerve innervation, VNS can activate the vagus afferent fibers, project to the central solitary nucleus (NTS), thereby enhancing the output activity of the sacral nerves and regulating the functions of the distal colon and rectum, achieving the therapeutic effect (25, 31)

Science 362 (6418), 10641069

Transporter occluded-state conformation-induced endocytosis: amino acid transporter atb0,+-mediated tumor targeting of liposomes for docetaxel delivery for hepatocarcinoma therapy

Comparing it to others can help create a diet good for kidneys

Dietary modulation of energy homoeostasis and metabolic-inflammation